2019
Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations.
Neuro Oncology. Feb 2019/21(8):968-980.
The power of human cancer genetics as revealed by low-grade gliomas.
Annual Review of Genetics. Dec 2019/53;483-503.
Old meet new-the path to combination treatments in pediatric low-grade gliomas.
Neuro Oncology. Feb 2019/21(2);143-145.
Mitogenic and progenitor gene programs in single pilocytic astrocytoma cells.
Nature Communications. August 2019/ 10(1):3731.
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature. 2019 Nov/575(7783);545-550.
2018
Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.
Journal of Neuro-Oncology. 2018 Nov; 140(2):269-279.
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
Cell Chem Biol. 2018 Jan; 25(1):88-99.
Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response.
J Neurooncology. April 2018/137(2):269-278..
2017
Brainstem angiocentric gliomas with MYB-QKI rearrangements.
Acta Neuropathology. 2017; 134(4):667-669.
A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas
Neuro Oncol. 2017 Jun; 19(6):774-785.
2016
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.
Nature Genetics. 2016 Mar;48(3):273-82.
2015
Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)
Pediatr Blood Cancer. 2015 Jan;62(1):3-4.
2014
A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer
Pediatr Blood Cancer. 2014 61(4):636-42.
An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells
J. Neuroscience. 2014 Jun; 34(25):8507-18.
Pediatric low-grade gliomas: How modern biology reshapes the clinical field
Biochem Biophys Acta. 2014 1845(2) 294-307.
Genome sequencing of SHH medulloblastoma predicts genoType-related response to smoothened inhibition
Cancer Cell. 2014 Mar 17;25(3):393-405.
Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling
Sci Transl Med. 2012 4(148) 148ra117.
Phase II trial of pirfenidone in children and young adults with neurofibromatosis Type 1 and progressive plexiform neurofibromas
Pediatr Blood Cancer. 2014 Sep;61(9):1598-602.
Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies
ACS Chem Biol. 2014 9(3):831-7.
Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy
J Clin Oncol. 2014 Aug 4. pii: JCO.2013.51.1766.
Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging
J Neurosurg Pediatr. Oct;14(4):356-64..
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.
Proc Natl Acad Sci USA. 2014 Jul: 111(30):11121-6.
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
Nat Genet. 2014 Feb;46(2):161-5.
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
PNAS. 2014 Nov 11;111(45):E4869-77.
2013
Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities
Nat Med. 2013 Nov 19(11):1518-23.
Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1611-6.
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
International Cancer Genome Consortium PedBrain Tumor Project. Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30. PMID:23817572.
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
Nat Genet. 2013 Aug: 45(8):927-32.
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1
Proc Natl Acad Sci USA. 2013 May 14;110(20):8188-93. PMID:23633565.
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR
Cancer Res. 2013 Apr 15;73(8):2574-86.
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state
Science. 2013 Jul 19; 341(6143). PMID:1238303.
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells
Nat Biotechnol. 2013 Jul; 31(7):630-7. PMID:23811600.
Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging
Sci Rep. 2013 Oct 4;3:2859. .
Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy
Sci Transl Med. 2013 Sep 4;5(201):201ra119.
PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
Brain Pathol. 2013 Sep;23(5):565-73. doi: 10.1111/bpa.12043. Epub 2013 Mar 18. PMID:23438035.
2012
Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors
Blood Cancer. 2012 Dec 15;59(7):1155-7. doi: 10.1002/pbc.24315. Epub 2012 Sep 19. PMID:2997201.
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas
Cancer Cell. 2012 Nov 13;22(5):668-82.
Systematic identification of genomic markers of drug sensitivity in cancer cells
Nature. 2012 Mar 28;483(7391):570-5.
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2
Nat Rev Neurosci. 2012 Dec;13(12):819-31. PMID:23165259.
2011
The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma
Cancer Cell. 2011 Mar 8;19(3):359-71.
Phosphorylation state of Olig2 regulates proliferation of neural progenitors
Neuron. 2011 Mar 10;69(5):906-17.
