The PLGA Program is investigating how the tumor micro-environment affects the growth and development of pediatric low-grade gliomas by asking questions such as why do tumors that express the KIAA1549-BRAF fusion genes only occur in the cerebellum? Tumors are mixtures of different cell types, including diverse types of cancer and non-cancer cells. This has implications for cancer treatment as distinct cancer cell types may respond differently to individual therapies. Moreover, immune cells present within a tumor can be harnessed to attack the cancer cells, an approach used in many other cancers such as melanoma. The Program’s researchers are taking two approaches to exploring the cellular diversity of tumors: developing culture systems for growing primary tumors in the laboratory and performing single cell RNA sequencing on individual tumor cells.
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About Nancy McNamara
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But we are proud to say that Nancy McNamara contributed 12 entries already.
Entries by Nancy McNamara
Low-grade astrocytomas are the most common form of pediatric brain cancer. While PLGA survival rates are high, many patients suffer life-long effects on cognitive and other functions. What our patients desperately need are new therapies that attack only cancer cells, leaving healthy cells unharmed. Key to understanding and defeating this disease is the fact that […]
On September 20, we all piled into the patio at Sweet Cheeks in Fenway for a fabulous “Appreciation Lunch” sponsored by the PLGA Fund families. It was a special day: the sun was shining; the food was delicious; and the good cheer flowed. It’s a rare occurrence for all the various members of the PLGA […]
The DFCI PLGA program congratulates our own Daphne Haas-Kogan, MD on her election to the National Academy of Medicine. This is one of the highest honors in the fields of health and medicine. Daphne is recognized for her research on genetic abnormalities of brain tumors and for successfully translating laboratory discovers to treatments. Please learn […]
John Ragnoni, Dr. Mimi Bandopadhayay and Amy Weinstein working hard, but still having fun at a recent PBTF meeting.
We had a great time the evening of June 12, 2019 when PMC team members came to visit. Dr. Mimi Bandopadhayay spoke and 6 of our young investigators gave updates on their work. The talks were followed by a check presentation and laboratory tours. The 2018 PMC teams raised $1,746,871.85 for the PLGA program! As […]
Bill Tiller, CEO of The Pediatric Brain Tumor Foundation (PBTF), Kimberly Roy-Canning, PBTF Northeast Regional Director, and John D’Ambrosio, PBTF Northeast Regional Campaign Manager came for a visit to DFCI on Tuesday, April 9, 2019. It was a lovely evening of presentations by the Dana-Farber PLGA program scientists, tours of the Jimmy Fund Clinic and […]
Team Nathan raised $157,967 riding in the 2018 PMC. They came for a lab visit and check presentation on Feb 13. It was a special evening and awesome opportunity for us to show what we do in the lab. Two teams, riders and scientists, together are a formidable force in the fight against PLGA!
We are most honored to announce that our Scientific Director, Rosalind Segal, MD, PhD, has won this year’s Edward J Benz Jr. Award for Advancing the Careers of Women Faculty. Roz is recognized for going “above and beyond to advance women’s careers,” and for “being a consummate role model.” Congratulations Roz!
Clinical Trials The Program’s clinical trials arm has two specific aims: the first is to improve the translation of laboratory findings into clinical trials for children with low-grade gliomas and the second is to increase the Program’s access to biological materials that can be used to support the scientific investigations. As the majority of pediatric […]