Day One Announces Preliminary Phase 1 Results for DAY101 in Pediatric Low-Grade Glioma, Receipt of Breakthrough Therapy Designation (BTD) and New Phase 2 Study

This is big news! The ability to inhibit oncogenic BRAF in PLGAs by DAY101 (formerly TAK580) was discovered right here at Dana-Farber by investigators supported by the PLGA Foundation. This therapy would not exist without the vision, determination and persistence of our team of families, donors, basic scientists, clinicians and industry. An amazing example of “Yes, together we can!”

Read more here.




Team DFCI Lab Rats is ready to #GearUpShowUpCare
See everyone at the first ever virtual Geared Up for Kids event this Sunday, May 31 at 7 PM.

To join us, please register here.

Pediatric low-grade astrocytomas

Pediatric Low-Grade Astrocytomas (PLGAs) need research now!

Pediatric low-grade astrocytomas are the most common form of childhood brain cancer.

Low-grade astrocytomas are the most common form of pediatric brain cancer.  While PLGA  survival rates are high, many patients suffer life-long effects on cognitive and other functions.  What our patients desperately need are new therapies that attack only cancer cells, leaving healthy cells unharmed.  Key to understanding and defeating this disease is the fact that brain cancer is a diverse collection of different tumor types.  Our multi-disciplinary team of basic research scientists and clinicians is characterizing this diversity in great molecular detail to identify unique vulnerabilities in cancer subtypes that can be exploited to therapeutic advantage.

PLGA Appreciation Lunch

PLGA Appreciation Lunch

On September 20, we all piled into the patio at Sweet Cheeks in Fenway for a fabulous “Appreciation Lunch” sponsored by the PLGA Fund families. It was a special day: the sun was shining; the food was delicious; and the good cheer flowed. It’s a rare occurrence for all the various members of the PLGA team, dedicated and busy folk, to be in one place with the ease to share our stories. Among the numerous speeches was a special “thank you” to Dr. Chuck Stiles for his many years of peerless leadership and selfless efforts championing the cause. “Inspiring” doesn’t really do justice to the mutually shared feelings that ensued, but it’s the only word that has a chance of coming close. And icing on the cake, we received awesome fleece vests with the beautiful PLGA Fund at PBTF logo! We appreciate the appreciation! Thank you all!

Daphne Haas-Kogan, MD

Congratulations Daphne on being elected to the National Academy of Medicine!

Daphne Haas-Kogan, MD

The DFCI PLGA program congratulates our own Daphne Haas-Kogan, MD on her election to the National Academy of Medicine. This is one of the highest honors in the fields of health and medicine. Daphne is recognized for her research on genetic abnormalities of brain tumors and for successfully translating laboratory discovers to treatments. Please learn more about this year’s NAM inductees at:

John, Mimi and Amy

John Ragnoni, Dr. Mimi Bandopadhayay and Amy Weinstein working hard, but still having fun at a recent PBTF meeting.

Team Nathan PMC Riders - Lab Visit and Check Presentation

PMC Teams Visit June 12, 2019

We had a great time the evening of June 12, 2019 when PMC team members came to visit. Dr. Mimi Bandopadhayay spoke and 6 of our young investigators gave updates on their work. The talks were followed by a check presentation and laboratory tours. The 2018 PMC teams raised $1,746,871.85 for the PLGA program! As […]

Welcome Bill, Kimberly and John!

Bill Tiller, CEO of The Pediatric Brain Tumor Foundation (PBTF), Kimberly Roy-Canning, PBTF Northeast Regional Director, and John D’Ambrosio, PBTF Northeast Regional Campaign Manager came for a visit to DFCI on Tuesday, April 9, 2019. It was a lovely evening of presentations by the Dana-Farber PLGA program scientists, tours of the Jimmy Fund Clinic and […]

Team Nathan PMC Riders - Lab Visit and Check Presentation

Team Nathan PMC Riders – Lab Visit and Check Presentation

Team Nathan raised $157,967 riding in the 2018 PMC. They came for a lab visit and check presentation on Feb 13. It was a special evening and awesome opportunity for us to show what we do in the lab.  Two teams, riders and scientists, together are a formidable force in the fight against PLGA!

Dana-Farber helps “Flip the Switch” with the Pediatric Brain Tumor Foundation

Dana-Farber’s Susan Chi, MD, Jill MacDonald, RN, BSN, CPON, Mimi Bandopadhayay, PhD, MBBS, and Larisa Condurat, PhD help the Pediatric Brain Tumor Foundation “Flip the Switch” on December 27th to light up the Prudential Center in support of pediatric brain tumor research.