Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

In our April featured publication, investigators from our Program and their collaborators analyzed the gene expression profiles of 151 pediatric low-grade glioma samples.  They discovered significant differences associated with the location of the tumor, the appearance of the tumor and BRAF mutation status.  In particular, supratentorial juvenile pilocytic astrocytomas were enriched with genes involved in inflammation.  These differences in tumor subtypes further our understanding of the role of location in the brain and the microenvironment of the tumor, and may lead to new targets for therapy in the future.