MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
In this month’s featured publication, researchers from the PLGA Program and their collaborators identify a new genetic driver of pediatric angiocentric glioma, called MYB-QKI. The genetic driver of angiocentric gliomas was previously unknown. MYB-QKI is an fusion protein that can drive tumor formation by several mechanisms, and its presence in a tumor sample provides an important diagnostic tool and an avenue for therapy in angiocentric glioma.