In October’s Featured Publication, Dr. Sandro Santagata treated a patient with BRAF V600E mutated pleomorphic xanthroastrocytoma (PXA), a rare brain tumor in children and young adults. His team used Vemurafenib monotherapy for the first time in the treatment of V600E-mutated glioma, and saw an encouraging response by the tumor to this approach, leading to the […]
In this article in Neuro Oncology, Dr Kieran and others from Dana-Farber Cancer Institute and Harvard Medical School report the results of the RAD001 clinical trial in pediatric patients. They show that treatment with RAD001 was well tolerated in patients with recurrent or progressive low-grade gliomas, and that incorporation of this drug into front line […]
In this month’s article in Journal of Neurosurgery: Pediatrics, Mark Kieran and colleagues studied the frequency of brain imaging (through MRI) a patient receives to evaluate how often tumors recurred. They found that at either 2 or 5 years of recurrence-free survival there were no clinical symptoms or mortality observed in the patient population studied, […]
This month’s featured publication by Dr. Kieran discusses the medulloblastoma subgroup with activations of the sonic hedgehog pathway, the preclinical data currently known and the development of novel therapies to overcome chemoresistance.
In this e-book chapter, Dr Kieran discusses the signalling molecule BRAF, and how mutations in BRAF can cause pediatric brain cancer. Also explained is how our scientists are beginning to understand the biology of BRAF signalling, and how these discoveries can be exploited for new therapy targets.
Congratulations to PLGA faculty member, Rosalind Segal, MD, PhD as she is appointed the new Director of the Program in Neuroscience at Harvard Medical School!
In this review article, Drs. Stiles, Segal, Beroukhim, Ligon and Kieran discuss low grade glioma clinical features, current therapies and new genomic discoveries, and how these most recent findings can be applied to diagnose and treat low grade tumors in the future.
Like softball and fun? Hate brain cancer? The 2nd Annual Old Man/Lady Softball Game is seeking players! Join in on August 16th at Greenie Park Newton NH. Last year was a huge success..this year the list is growing larger with so many more activities planned. Admission is $20 to play/ $2 admission. There will be […]
Did you miss the webinar on May 5th? View a recording of our Clinical Director, Dr. Mark Kieran’s webinar where he discussed result of his recent study of long-term clinical outcomes. This unprecedented study finally quantifies what outcomes look like for LGG kids who have undergone the front-line treatment protocols (surgery, chemotherapy and radiation). Understanding […]
On March 12th, our PLGA Program Scientific Director was awarded the 2014 Casty Family Achievement in Mentoring Award. Many of Dr. Stiles’ past and present trainees attended the event held at Dana-Farber Cancer Institute, and enjoyed a look back over Dr Stiles’ career as a scientist and mentor. Congratulations Dr Stiles!
