Entries by Tam

Final results of a prospective multi-institutional phase II study of everolimus (rad001), an mtor inhibitor, in pediatric patients with recurrent or progressive low-grade glioma. A poetic consortium trial.

In this article in Neuro Oncology, Dr Kieran and others from Dana-Farber Cancer Institute and Harvard Medical School report the results of the RAD001 clinical trial in pediatric patients.  They show that treatment with RAD001 was well tolerated in patients with recurrent or progressive low-grade gliomas, and that incorporation of this drug into front line […]

Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging.

In this month’s article in Journal of Neurosurgery: Pediatrics, Mark Kieran and colleagues studied the frequency of brain imaging (through MRI) a patient receives to evaluate how often tumors recurred.  They found that at either 2 or 5 years of recurrence-free survival there were no clinical symptoms or mortality observed in the patient population studied, […]

Targeting BRAF in Pediatric Brain Tumors

In this e-book chapter, Dr Kieran discusses the signalling molecule BRAF, and how mutations in BRAF can cause pediatric brain cancer.   Also explained is how our scientists are beginning to understand the biology of BRAF signalling, and how these discoveries can be exploited for new therapy targets.

View the webinar here- Dr. Mark Kieran “Long Term Survivorship Outcomes for Children Battling Low Grade Glioma Brain Tumors”

Did you miss the webinar on May 5th?  View a recording  of our Clinical Director, Dr. Mark Kieran’s webinar where he discussed result of his recent study of long-term clinical outcomes.  This unprecedented study finally quantifies what outcomes look like for LGG kids who have undergone the front-line treatment protocols (surgery, chemotherapy and radiation). Understanding […]

Casty Family Award for Achievement in Mentoring 2014

On March 12th, our PLGA Program Scientific Director was awarded the 2014 Casty Family Achievement in Mentoring Award.  Many of Dr. Stiles’ past and present trainees attended the event held at Dana-Farber Cancer Institute, and enjoyed a look back over Dr Stiles’ career as a scientist and mentor.  Congratulations Dr Stiles!

Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: An analysis of the Surveillance Epidemiology and End Results (SEER) database, Pediatric Blood and Cancer

This paper, published in Pediatric Blood and Cancer, is a collaboration between work carried out in the laboratory of Rameen Beroukhim, MD, PhD and clinical data from Mark Kieran, MD, PhD. The researchers examined the long-term survival rates of adults who had low-grade gliomas as children. Here they show that patients with previous disease have […]