#GearUpShowUpCare Team DFCI Lab Rats is ready to #GearUpShowUpCare See everyone at the first ever virtual Geared Up for Kids event this Sunday, May 31 at 7 PM. To join us, please register here.
Author Archive for: Tam
This author has yet to write their bio.Meanwhile lets just say that we are proud Tam contributed a whooping 41 entries.
Entries by Tam
Dr. Mike Eck and colleagues have published their tour de force structural study of BRAF in complex with MEK and 14-3-3 dimers. This work explains longstanding questions about the biochemical behavior of BRAF and provides a foundation for understanding BRAF activation by oncogenic mutations as well as pharmacologic inhibition. Please go to: https://www.ncbi.nlm.nih.gov/pubmed/31581174 to read […]
In this featured publication, lead authors Zachary Reitman, MD, PhD and Brenton Paolella, PhD, and others with Mimi Bandopadhayay, MBBS, PhD and Rameen Beroukhim, MD, PhD use single cell sequencing technology to examine the cellular state of individual tumor cells. They find that PA cancer cells often look like astrocytes at the RNA level, but […]
In this featured publication, investigators review recent results of treatments for pediatric low-grade gliomas, including standard chemotherapy, therapies targeting the mitogen-activated protein kinase (MAPK) pathway, and proton-beam radiation therapy.
Dana-Farber’s Susan Chi, MD, Jill MacDonald, RN, BSN, CPON, Mimi Bandopadhayay, PhD, MBBS, and Larisa Condurat, PhD help the Pediatric Brain Tumor Foundation “Flip the Switch” on December 27th to light up the Prudential Center in support of pediatric brain tumor research.
Team Lab Rats had so much fun this year and raised some $ too! We can’t wait to bike/run/walk again next year! In the meantime, we’ll be working hard in the lab.
In this featured publication, Drs. Bandopadhyay and Ligon examine the potential for using the MYB-QKI rearrangement as a diagnostic marker in ambiguous or atypical low-grade glioma cases.
In this month’s featured publication, Drs. Hahn and Beroukhim and colleagues present REVEALER, a computational tool to investigate the functional consequences of the many mutations identified in tumor samples. Distinguishing “driver” mutations that underlie oncogenic phenotypes from “passenger” mutations with no evident functional consequences is critical to the development of effective targeted therapies. This publication demonstrates the ability of […]
The DFCI Lab Rats are running, walking and biking at 2018’s Geared Up for Kids! Please visit our page to join our team and donate!
In this month’s featured publication, Dr. Ligon and colleagues analyzed 134 diffuse intrinsic pontine glioma (DIPG) samples for their genetic make-up. They determined that the DIPG tumors are associated with a particular mutation H3K27M, which is the initial driver of tumor formation, and that this mutation is maintained throughout the course of disease. These findings […]