Entries by Tam

#GearUpShowUpCare

#GearUpShowUpCare Team DFCI Lab Rats is ready to #GearUpShowUpCare See everyone at the first ever virtual Geared Up for Kids event this Sunday, May 31 at 7 PM. To join us, please register here.

Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes

Dr. Mike Eck and colleagues have published their tour de force structural study of BRAF in complex with MEK and 14-3-3 dimers. This work explains longstanding questions about the biochemical behavior of BRAF and provides a foundation for understanding BRAF activation by oncogenic mutations as well as pharmacologic inhibition. Please go to: https://www.ncbi.nlm.nih.gov/pubmed/31581174 to read […]

Geared Up for Kids 2018

Team Lab Rats had so much fun this year and raised some $ too! We can’t wait to bike/run/walk again next year! In the meantime, we’ll be working hard in the lab.  

Characterizing genomic alterations in cancer by complementary functional associations

In this month’s featured publication, Drs. Hahn and Beroukhim and colleagues present REVEALER, a computational tool to investigate the functional consequences of the many mutations identified in tumor samples.  Distinguishing “driver” mutations that underlie oncogenic phenotypes from “passenger” mutations with no evident functional consequences is critical to the development of effective targeted therapies. This publication demonstrates the ability of […]

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

In this month’s featured publication, Dr. Ligon and colleagues analyzed 134 diffuse intrinsic pontine glioma (DIPG) samples for their genetic make-up.  They determined that the DIPG tumors are associated with a particular mutation H3K27M, which is the initial driver of tumor formation, and that this mutation is maintained throughout the course of disease.  These findings […]