Dr. Mike Eck and colleagues have published their tour de force structural study of BRAF in complex with MEK and 14-3-3 dimers. This work explains longstanding questions about the biochemical behavior of BRAF and provides a foundation for understanding BRAF activation by oncogenic mutations as well as pharmacologic inhibition. Please go to: https://www.ncbi.nlm.nih.gov/pubmed/31581174 to read the abstract and learn more. Congratulations to Mike and his scientific team!
https://www.danafarberplga.org/wp-content/uploads/2019/10/Nature.jpeg 200 200 Tam /wp-content/uploads/2020/04/PLGA-DFCI-logo-left-title-right-v6.jpg Tam2019-10-07 18:44:072020-03-26 16:55:46Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes