Targeted treatment for sonic hedgehog-dependent medulloblastoma

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2This month’s featured publication by Dr. Kieran discusses the medulloblastoma subgroup with activations of the sonic hedgehog pathway, the preclinical data currently known and the development of novel therapies to overcome chemoresistance.

Targeting BRAF in Pediatric Brain Tumors

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PET-imageIn this e-book chapter, Dr Kieran discusses the signalling molecule BRAF, and how mutations in BRAF can cause pediatric brain cancer.   Also explained is how our scientists are beginning to understand the biology of BRAF signalling, and how these discoveries can be exploited for new therapy targets.