In this month’s featured publication, Dr. Ligon and colleagues analyzed 134 diffuse intrinsic pontine glioma (DIPG) samples for their genetic make-up. They determined that the DIPG tumors are associated with a particular mutation H3K27M, which is the initial driver of tumor formation, and that this mutation is maintained throughout the course of disease. These findings […]
Author Archive for: Tam
This author has not written his bio yet.
But we are proud to say that Tam contributed 42 entries already.
Entries by Tam
In this month’s Featured Publication, Dr. Kieran and colleagues studied the outcomes of adult survivors of pediatric low-grade glioma over a 27 year span. They found that overall, patients showed excellent long-term survival, but this was somewhat decreased in patients who had received upfront radiotherapy. The article suggests that these observations be considered when treatment […]
In this month’s featured publication, researchers from the PLGA Program and their collaborators identify a new genetic driver of pediatric angiocentric glioma, called MYB-QKI. The genetic driver of angiocentric gliomas was previously unknown. MYB-QKI is an fusion protein that can drive tumor formation by several mechanisms, and its presence in a tumor sample provides an […]
In this month’s featured publication, Drs. Segal and Stiles describe a new system to culture primary brain tumor types that otherwise prove difficult to propagate. This culture system enables the team to investigate the role of the tumor microenvironment, and to test potential therapies on tumor cell growth.
Loren Walensky, MD, PhD, Associate Professor of Pediatrics, Dana-Farber Cancer Institute and Harvard Medical School, and Principal Investigator, Linde Program in Cancer Chemical Biology, speaks about collaborative drug discovery that is taking place at Dana-Farber Cancer Institute’s Longwood Center.
In this month’s featured publication, Drs. Ligon, Beroukhim, Kieran and colleagues published a study of the treatment and outcome of children with myxopapillary ependymomas (MPE), a rare spinal tumor. They examined the diagnosis, imaging, treatment and clinical outcome of eighteen children over a period of 30 years, and found patients with MPE have an excellent […]
Team Dana-Farber Lab Rats walked, ran and biked to raise funds for children’s brain tumor research. Many thanks to Rick Bern for the photograph!
In this month’s featured publication, Drs. Santagata, Ligon, and Beroukhim and colleagues published a study where they analyzed brain metastases for alterations in their genetic profiles. In about half of the cases they found different genetic alterations in the brain metastases when compared with the primary tumor site. This study showed that the genetically […]
In September’s featured publication, Dr. Nathalie Agar and colleagues show how mass spectrometry imaging can be used to detect pituitary tumors during surgery. This technology may allow surgeons to characterize between the tumor and healthy tissue border in 30 minutes or less, and can be applied for near-real-time detection and surgical decision-making.
In August’s featured publication, Dr. Kieran and his collaborators discuss diffuse intrinsic pontine glioma (DIPG), and the role of epigenetic and genetic mutations within these tumors that will allow the development of novel therapies in the future.